PEA with Levagen, is an Amino Acid naturally produced in the body. It is known to hold anti-inflammatory properties, possibly reducing inflammation and easing chronic pain. Levagen has twice the absorption, giving you an average dose of 600mg per capsule.

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Original price was: $28.48.Current price is: $15.00.

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PEA with Levagen for Sale

What is Palmitoylethanolamide PEA with Levagen?

Palmitoylethanolamide (PEA) with Levagen is a natural compound known for its potential ability in managing chronic pain, including joint pain. As an endogenous fatty acid amide, PEA naturally occurs in the body and possesses anti-inflammatory properties, making it valuable in treating various pain conditions, notably those involving inflammation like arthritis.

PEA acts as a signaling molecule, regulating pain and inflammation. By modulating these processes, it can alleviate pain in the joints. Moreover, PEA has been linked to promoting restful sleep. Chronic pain often disrupts sleep patterns, creating a cycle of discomfort and sleep disturbances. Addressing underlying inflammation and pain, PEA has the potential to enhance sleep quality in individuals dealing with pain.

Levagen, a specialized form of PEA, enhances its bioavailability and effectiveness, making it a popular choice for natural remedies in chronic pain and inflammatory conditions. By optimizing PEA’s benefits, the combination with Levagen offers a potential solution for persistent pain and inflammation.

How Palmitoylethanolamide PEA with Levagen Work?

Palmitoylethanolamide (PEA) with Levagen operates through a multifaceted mechanism of action, harnessing the anti-inflammatory, pain relief, and neuroprotective properties of PEA while enhancing its bioavailability for maximum effectiveness. PEA, as an endogenous fatty acid amide, targets the peroxisome proliferator-activated receptor alpha (PPAR-alpha), downregulating inflammatory processes and reducing the production of pro-inflammatory molecules. Additionally, PEA interacts with cannabinoid receptors (CB1 and CB2) of our body’s endocannabinoid system, modulating pain perception and providing pain relief and joint stiffness.

PEA also exerts neuroprotective effects by inhibiting microglial activation, safeguarding nerve cells from inflammation-induced damage. Furthermore, PEA restores cellular homeostasis by stabilizing mast cell activity, promoting a balanced inflammatory response. The specialized formulation, Levagen, enhances PEA’s bioavailability, ensuring higher absorption rates and allowing for a more effective impact on the body.

By combining these mechanisms, Palmitoylethanolamide with Levagen offers a completely legal solution unlike CBD, for managing chronic pain and inflammatory conditions, potentially improving the overall quality of life for individuals grappling with persistent pain issues.

Prometheuz Health Palmitoylethanolamide PEA with Levagen Benefits

Chronic Pain Management

Palmitoylethanolamide stands out for its potential to reduce pain conditions such as pelvic pain, neuropathic pain, and knee osteoarthritis. Supported by research such as a comprehensive 2016 review published in the Journal of Pain Research, PEA’s anti-inflammatory properties have been highlighted. This natural compound is believed to modulate immune responses and reduce inflammation, which are key factors in managing persistent pain. By targeting these pathways, PEA offers a promising approach to providing relief to individuals suffering from chronic pain, potentially enhancing their overall quality of life. [R]

Anti-Inflammatory Effects

Numerous studies, including notable research featured in Inflammation Research in 2010, have illuminated PEA’s profound anti-inflammatory effects. Its mechanism involves precise interactions with receptors implicated in the immune response. By influencing these receptors, PEA has demonstrated its ability to mitigate inflammation. This property makes it a valuable candidate in the treatment of inflammatory conditions, showcasing its potential in managing a range of disorders where inflammation plays a pivotal role. [R]

Neuroprotective Properties

Recent studies, exemplified by research in the European Journal of Pharmacology in 2015, have unveiled PEA’s neuroprotective properties. One of its key actions involves inhibiting microglial activation, a process linked to neuroinflammation. By preventing the overactivation of these immune cells within the central nervous system, PEA has emerged as a compelling subject in neurological research. Its neuroprotective potential hints at applications in disorders where neural preservation is crucial, offering new avenues for exploration in the field of neurology. [R]

Enhanced Bioavailability

Levagen, meticulously designed to optimize the effectiveness of PEA, focuses on enhancing bioavailability. While specific studies on Levagen might be limited, the fundamental principle is clear: improved bioavailability ensures a higher percentage of the administered substance reaches the bloodstream. In the realm of pharmaceutical and supplement development, this goal is paramount. By enhancing the bioavailability of PEA, Levagen potentially maximizes the impact of this natural compound, promising more efficient absorption and utilization within the body. [R]

Superior Absorption

Although not exclusive to Levagen, the concept of improving absorption is a central theme in the pharmaceutical industry. Techniques aimed at enhancing the absorption of compounds, such as PEA, are of great interest. Efficient absorption translates to a more pronounced therapeutic effect. This focus on absorption methods underscores the industry’s commitment to refining treatments, emphasizing the importance of maximizing the body’s ability to utilize therapeutic agents effectively. Techniques like those associated with Levagen represent a progressive step toward optimizing the absorption and, consequently, the therapeutic potential of compounds like PEA. [R]

How To Take Prometheuz Health Palmitoylethanolamide with Levagen

Read the Label: Carefully read the label and follow the recommended dosage instructions provided by the manufacturer. Pay attention to whether the supplement should be taken with or without food.

Consult a Healthcare Professional: Before starting any new supplement regimen, especially if you have underlying health conditions or symptoms, are pregnant or nursing, or are taking other medications, consult with a healthcare professional. They can give you tailored advice based on your specific health requirements.

Start with the Recommended Dose of Standard PEA Formulation: Begin with the recommended dose suggested on the label. Unless otherwise directed by a healthcare provider, do not exceed the recommended dose. Some supplements can have adverse effects in high amounts.

Stay Hydrated: Take supplements with a full glass of water, unless otherwise directed. Hydration is important for supplement absorption.

Store Properly: Store supplements as directed on the label. Some supplements need to be kept in the refrigerator, while others should be stored in a cool, dry place. Proper storage ensures the supplement remains effective and safe to consume.

Prometheuz Health Palmitoylethanolamide with Levagen Ingredient Benefits

Benefits of PEA (Palmitoylethanolamide)

Pain Management

PEA has shown significant potential in managing various types of pain, especially chronic pain conditions. It does so by modulating inflammation and targeting pain receptors, providing relief to individuals suffering from conditions like neuropathic pain, fibromyalgia, and sciatic pain. [R]

Anti-Inflammatory Properties

PEA possesses anti-inflammatory effects, making it valuable in treating inflammatory conditions such as arthritis, multiple sclerosis, and endometriosis. By reducing inflammation, it can alleviate symptoms and improve overall well-being. [R]


PEA has neuroprotective properties, safeguarding nerve cells from damage caused by inflammation. This makes it a subject of interest in neurological disorders and neurodegenerative diseases, offering potential therapeutic avenues in conditions like Alzheimer’s and Parkinson’s disease. [R]

Immune Modulation

PEA modulates the immune response, contributing to its anti-inflammatory effects. By regulating immune activity, it can help maintain a balanced immune system, potentially benefiting individuals with autoimmune disorders. [R]

Mood and Well-being

Some studies suggest that PEA may have a positive impact on mood and well-being. By reducing pains and inflammation, it could indirectly enhance mental health by relieving stress and improving overall quality of life. [R]

Benefits of Levagen

Enhanced Bioavailability

Levagen is designed to enhance the bioavailability of PEA, ensuring a higher proportion of the ingested substance reaches the bloodstream. This enhanced bioavailability leads to more efficient utilization of PEA in the body, amplifying its therapeutic effects. [R]

Optimized Absorption

By improving the absorption of PEA, Levagen maximizes its impact on the body. Efficient absorption means the active ingredient is utilized effectively, enhancing its potential benefits in pain management, anti-inflammatory actions, and neuroprotection. [R]

Synergistic Effects

Levagen, in combination with PEA, offers synergistic effects. By optimizing PEA’s absorption and bioavailability, Levagen amplifies the natural properties of PEA, potentially magnifying its health benefits. This synergy enhances its effectiveness in managing pain, and inflammation, and promoting overall well-being. [R]

Prometheuz Health Palmitoylethanolamide with Levagen Side Effects and Warnings

Palmitoylethanolamide is generally well-tolerated with an excellent safety profile, making it a promising option for managing chronic pain and inflammation. Derived from a naturally occurring fatty acid amide produced in the body, PEA supplements have been extensively studied, and adverse effects are rare. It’s worth noting that PEA supplements, especially those labeled as non-GMO, are designed to enhance the body’s natural processes.

Research has shown that PEA has a favorable safety profile even at significant amounts and does not cause significant side effects. Additionally, PEA is rapidly metabolized and excreted, leading to a short half-life and ensuring that it does not accumulate in the body. However, individuals considering PEA supplementation should always consult with a healthcare professional, especially if they have existing medical conditions or are taking other medications.

Monitoring plasma PEA concentration might be essential in certain cases to ensure it remains within the optimal range for therapeutic effects. While PEA generally presents minimal risks, individual responses can vary, so it is crucial to discuss any concerns with a healthcare provider before incorporating PEA supplements into a daily regimen.

Frequently Asked Questions

How does PEA with Levagen compare to nonsteroidal anti-inflammatory drugs (NSAIDs) in managing pain and inflammation?

PEA with Levagen offers a safer alternative to NSAIDs. Unlike NSAIDs, PEA with Levagen does not carry the risk of gastrointestinal issues or adverse effects on kidney function. It effectively manages pain and inflammation without the drawbacks associated with traditional anti-inflammatory medications.

Can PEA with Levagen improve joint function and overall body health?

Potentially, studies have shown that PEA with Levagen may improve joint function by reducing inflammation. Its anti-inflammatory properties contribute to joint health and overall body health, providing relief from chronic pain conditions and promoting well-being.

Is there scientific evidence supporting the effectiveness of PEA with Levagen?

Yes, PEA with Levagen has been studied extensively in a double-blind, placebo-controlled study conducted with female volunteers, which demonstrated to reduce pain, improved sleep onset time, and enhanced joint function compared to a placebo group. These findings affirm the efficacy of PEA with Levagen in managing pain and promoting restful sleep. [R]

Can PEA with Levagen be considered as a treatment for Alzheimer’s disease?

While research is ongoing, some studies have indicated that PEA with Levagen might have neuroprotective properties. However, it is essential to consult with healthcare professionals for any potential use in Alzheimer’s disease, as the research is still in the early stages. [R]


The information provided about supplements is for general informational purposes only and should not be considered professional advice. Dietary supplements can have varying effects on different individuals based on factors such as age, health status, allergies, and medical history. Before starting any new supplement, it is essential to consult with a qualified healthcare professional or a registered dietitian.

Furthermore, the content provided does not endorse or promote any specific supplement brand or product. Always read the labels, warnings, and instructions provided by the manufacturer before using any supplement. It is crucial to follow the recommended dosage and not exceed the suggested intake without consulting a healthcare professional.

Individual results may vary, and they are not intended to diagnose, treat, cure, or prevent any disease or health condition. If you are pregnant, nursing, have a medical condition or are taking medication, consult your physician before using any supplements.

Additionally, supplements should not be used as a substitute for a balanced diet and healthy lifestyle. It is important to maintain a varied and balanced diet, engage in regular physical activity, and get adequate sleep to support overall health and well-being.

By using this information, you agree to release the provider from any and all liability for any claims or damages that may result from your use of supplements based on the information provided. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition.


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