Symptoms of Parkinson’s Disease
The slowly developing symptoms start with some tremors in one hand or stiffness and slowing of different bodily movements. The symptoms of the disease are different for different people, some symptoms are easily detected while some are even impossible for doctors to identify.
Motor Symptoms
Motor symptoms are what doctors mostly use to help identify the disease and make a diagnosis. These are easily noticeable, the three major motor symptoms for Parkinson’s disease are
1. Tremors
The involuntary shaking of fingers, hands or limbs when they are relaxed but ends when they are being voluntarily moved.
2. Stiffness
Stiffness in the muscles that is mostly detected on examination by doctors.
3. Slowness
It slows your voluntary movements over time; so that your steps become shorter and shorter, your arms stop swinging while walking and your facial expressions and blinking slows down.
4. Note
This does not mean everyone faces the same motor symptoms or all three of them when they get Parkinson’s disease.
Non Motor Symptoms
There are also the invisible unseeable symptoms of Parkinsons. These symptoms can occur at any time in the course of this disease and these too differ from person to person. These non motor symptoms include:
1. Low Blood Pressure & Constipation
Decrease in blood pressure from the smallest movements.
Difficulty in bowel movement.
2. Sexual Problems & Apathy
Decrease in libido for men and women and erectile dysfunction in men.
Lack of interest in activities.
3. Mood swings & Cognitive Problems
Mood swings ranging from depression to anxiety. Cognitive impairment form losing concentration to dementia.
4. Weight changes & Speech problems
Moderate weight loss in some patients.
Speech becomes slow and starts to slur.
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Causes of Parkinson’s Disease
Genetics
Scientists believe that about 30 percent of Parkinson’s risk can be explained away through genetics. Researchers
Environmental Factors
One other factor that increases the chances of developing Parkinson’s disease include exposure to pesticides and head traumas,
Age
Age is one of the major causes of Parkinson’s disease. Scientists believe that the number of people with Parkinson’s
Neurological causes of Parkinson’s
Mitochondrial Dysfunction
A lot of research has been done on Parkinson’s disease and studies show that mitochondrial dysfunction is the lead problem that causes Parkinson’s. Mitochondrial dysfunction impaires ATP generation
Lewy Bodies
Lew bodies are formed due to the dysfunction of the mitochondria. Lewy bodies formation is considered to be a marker for neuronal degeneration, because neuronal loss is found in the predilection sites for lewy bodies.
Neural Inflammation
Scientists hypothesize that the αlpha-synucleins secreted activate the glial cells which induce neuronal inflammation. The activated glial cells encourage the production of proinflammatory cytokines,